|
|
an_L-amino_acid + H2O + NAD+ <=> a_2-oxo_carboxylate + NH3 + NADH + H+
|
1.4.1.5
L-amino-acid dehydrogenase
|
–
|
|
|
BRENDA:
BR1253
KEGG:
R01258
MetaCyc:
L-AMINO-ACID-DEHYDROGENASE-RXN
|
|
|
|
a_2-oxo_carboxylate + H+ <=> an_aldehyde + CO2
|
4.1.1.1
pyruvate decarboxylase
|
–
|
|
|
BRENDA:
BR12746
KEGG:
R00636
MetaCyc:
PYRUVATE-DECARBOXYLASE-RXN
|
|
|
|
2-Oxoaldehydes + H2O + NAD+ <=> a_2-oxo_carboxylate + NADH + H+
|
1.2.1.23
2-oxoaldehyde dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BR29394;
BS189166
KEGG:
R01337
MetaCyc:
2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN
|
|
|
|
2-Oxoaldehydes + H2O + NADP+ <=> a_2-oxo_carboxylate + NADPH + H+
|
1.2.1.49
2-oxoaldehyde dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BR29408;
BS189256
KEGG:
R01338
MetaCyc:
2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN
|
|
|
|
(R)-2-hydroxyacid + NADP+ <=> a_2-oxo_carboxylate + NADPH + H+
|
1.1.1.272
D-2-hydroxyacid dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BR36717
KEGG:
R10528
MetaCyc:
1.1.1.272-RXN
|
|
|
|
O2 + (S)-2-hydroxyacid <=> H2O2 + a_2-oxo_carboxylate
|
1.1.3.15
(S)-2-hydroxy-acid oxidase
|
–
|
|
|
BRENDA:
BR36733
KEGG:
R01341
MetaCyc:
S-2-HYDROXY-ACID-OXIDASE-RXN
|
|
|
|
a_D-amino_acid + H2O + O2 <=> a_2-oxo_carboxylate + NH3 + H2O2
|
1.4.3.3
D-amino-acid oxidase
|
–
|
|
|
BRENDA:
BR36880
KEGG:
R01340
MetaCyc:
D-AMINO-ACID-OXIDASE-RXN
|
|
|
|
L-alanine + a_2-oxo_carboxylate <=> pyruvate + an_L-amino_acid
|
2.6.1.12
alanine---oxo-acid transaminase
|
–
|
|
|
BRENDA:
BR47384
KEGG:
R01261
MetaCyc:
ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN
|
|
|
|
(R)-2-hydroxyacid + acceptor <=> a_2-oxo_carboxylate + reduced_acceptor
|
1.1.99.30
2-oxo-acid reductase
|
–
|
|
|
BRENDA:
BR48024
KEGG:
R07155
MetaCyc:
1.1.99.30-RXN
|
|
|
|
(S)-2-hydroxyacid + NAD+ <=> a_2-oxo_carboxylate + NADH + H+
|
1.1.1.337
L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.375
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.99
(S)-2-hydroxy-fatty-acid dehydrogenase
|
–
–
–
|
|
|
BRENDA:
BR50230
KEGG:
R10189
MetaCyc:
RXN-13927;
RXN-15632_WOP
|
|
|
|
(R)-2-hydroxyacid + NAD+ <=> a_2-oxo_carboxylate + NADH + H+
|
1.1.1.345
D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.98
(R)-2-hydroxy-fatty-acid dehydrogenase
|
–
–
|
|
|
BRENDA:
BR50379;
BS440043
KEGG:
R10222
MetaCyc:
RXN-14183
|
|
|
|
a_2-oxo_carboxylate + CoA + oxidized_ferredoxin <=> acyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.11
2-oxoacid oxidoreductase (ferredoxin)
|
–
|
|
|
BRENDA:
BR50605
KEGG:
R10516
MetaCyc:
RXN-14474
|
|
|
|
(S)-2-hydroxyacid + NADP+ <=> a_2-oxo_carboxylate + NADPH + H+
|
1.1.1.375
L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
|
–
|
|
|
BRENDA:
BR51079
KEGG:
R10786
MetaCyc:
RXN-15632
|
|
|
|
an_aliphatic_L-amino_acid + H2O + O2 <=> a_2-oxo_carboxylate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
|
–
|
|
|
BRENDA:
BR36879
KEGG:
R01259
|
|
|
|
L-ornithine + a_2-oxo_carboxylate <=> L-glutamate_5-semialdehyde + an_aliphatic_L-amino_acid
|
2.6.1.13
ornithine aminotransferase
|
–
|
|
|
BRENDA:
BR47442
KEGG:
R01343
|
|
|
|
a_D-amino_acid + H2O + a_quinone <=> a_2-oxo_carboxylate + NH3 + a_quinol
|
1.4.5.1
D-amino acid dehydrogenase (quinone)
|
–
|
B
|
|
BRENDA:
BR49167
KEGG:
R09493
|
|
|
|
L-methionine + a_2-oxo_carboxylate <=> 4-methylsulfanyl-2-oxobutanoate + an_aliphatic_L-amino_acid
|
2.6.1.88
methionine transaminase
|
–
|
K
|
|
BRENDA:
BR49829
KEGG:
R08618
|
|
|
|
(R)-2-hydroxyacid + a_quinone <=> a_2-oxo_carboxylate + a_quinol
|
1.1.5.10
D-2-hydroxyacid dehydrogenase (quinone)
|
–
|
|
|
BRENDA:
BR50933
KEGG:
R10625
|
|
|
|
amino_acid + H2O + NAD+ <=> a_2-oxo_carboxylate + NH3 + NADH + H+
|
1.4.1.1
alanine dehydrogenase
1.4.1.10
glycine dehydrogenase
1.4.1.12
2,4-diaminopentanoate dehydrogenase
1.4.1.15
lysine dehydrogenase
1.4.1.19
tryptophan dehydrogenase
1.4.1.2
glutamate dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
1.4.1.3
glutamate dehydrogenase [NAD(P)+]
1.4.1.4
glutamate dehydrogenase (NADP+)
1.4.1.5
L-amino-acid dehydrogenase
1.4.1.7
serine 2-dehydrogenase
1.4.1.8
valine dehydrogenase (NADP+)
1.4.1.9
leucine dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
|
KEGG:
R00145
|
|
|
|
amino_acid + H2O + NADP+ <=> a_2-oxo_carboxylate + NH3 + NADPH + H+
|
1.4.1.1
alanine dehydrogenase
1.4.1.10
glycine dehydrogenase
1.4.1.12
2,4-diaminopentanoate dehydrogenase
1.4.1.15
lysine dehydrogenase
1.4.1.19
tryptophan dehydrogenase
1.4.1.2
glutamate dehydrogenase
1.4.1.20
phenylalanine dehydrogenase
1.4.1.3
glutamate dehydrogenase [NAD(P)+]
1.4.1.4
glutamate dehydrogenase (NADP+)
1.4.1.5
L-amino-acid dehydrogenase
1.4.1.7
serine 2-dehydrogenase
1.4.1.8
valine dehydrogenase (NADP+)
1.4.1.9
leucine dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
–
–
–
|
|
|
KEGG:
R00146
|
|
|
|
L-aspartate + a_2-oxo_carboxylate <=> amino_acid + oxaloacetate
|
2.6.1
|
–
|
|
|
KEGG:
R00493
|
|
|
|
a_2-oxo_carboxylate + L-glutamate <=> amino_acid + 2-oxoglutarate
|
not assigned
|
–
|
|
|
KEGG:
R01339
|
|
|
|
amino_acid + H2O + acceptor <=> a_2-oxo_carboxylate + NH3 + reduced_acceptor
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
KEGG:
R01342
|
|
|
|
a_D-amino_acid + pyruvate <=> a_2-oxo_carboxylate + D-alanine
|
2.6.1.21
D-amino-acid transaminase
|
–
|
K
|
|
KEGG:
R01344
|
|
|
|
L-asparagine + a_2-oxo_carboxylate <=> 2-oxosuccinamic_acid + an_L-amino_acid
|
2.6.1.14
asparagine---oxo-acid transaminase
|
–
|
K
|
|
KEGG:
R01346
|
|
|
|
D-ornithine + a_2-oxo_carboxylate <=> 5-amino-2-oxopentanoate + a_D-amino_acid
|
2.6.1.21
D-amino-acid transaminase
|
–
|
K
|
|
KEGG:
R02459
|
|
|
|
D-Lysine + a_2-oxo_carboxylate <=> 6-Amino-2-oxohexanoate + a_D-amino_acid
|
2.6.1.21
D-amino-acid transaminase
|
–
|
K
|
|
KEGG:
R02851
|
|
|
|
D-arginine + a_2-oxo_carboxylate <=> 5-guanidino-2-oxopentanoate + a_D-amino_acid
|
2.6.1.21
D-amino-acid transaminase
|
–
|
K
|
|
KEGG:
R02924
|
|
|
|
5-hydroxy-L-kynurenine + a_2-oxo_carboxylate <=> 4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate + amino_acid
|
2.6.1
|
–
|
K
|
|
KEGG:
R04913
|
|
|
|
amino_acid + H2O + O2 <=> a_2-oxo_carboxylate + NH3 + H2O2
|
1.4.3.1
D-aspartate oxidase
1.4.3.11
L-glutamate oxidase
1.4.3.2
L-amino-acid oxidase
1.4.3.3
D-amino-acid oxidase
1.4.3.7
D-glutamate oxidase
|
–
–
–
–
–
|
|
|
KEGG:
R06124
|
|
|
|
amino_acid <=> a_2-oxo_carboxylate + NH3
|
4.3.1.17
L-serine ammonia-lyase
4.3.1.18
D-serine ammonia-lyase
4.3.1.19
threonine ammonia-lyase
4.3.1.20
erythro-3-hydroxy-L-aspartate ammonia-lyase
|
–
–
–
–
|
|
|
KEGG:
R06131
|
|
|
|
a_D-amino_acid + H2O + acceptor <=> a_2-oxo_carboxylate + NH3 + reduced_acceptor
|
1.4.99.6
D-arginine dehydrogenase
|
–
|
|
|
KEGG:
R07166
|
|
|
|
2-Oxo-5-methylthiopentanoic_acid + an_L-amino_acid <=> L-homomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R08622
|
|
|
|
2-Oxo-6-methylthiohexanoic_acid + an_L-amino_acid <=> L-dihomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R08626
|
|
|
|
2-Oxo-7-methylthioheptanoic_acid + an_L-amino_acid <=> L-trihomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R08630
|
|
|
|
2-Oxo-8-methylthiooctanoic_acid + an_L-amino_acid <=> L-tetrahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R08638
|
|
|
|
2-Oxo-9-methylthiononanoic_acid + an_L-amino_acid <=> L-pentahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R08643
|
|
|
|
2-Oxo-10-methylthiodecanoic_acid + an_L-amino_acid <=> L-hexahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R08647
|
|
|
|
amino_acid + a_2-oxo_carboxylate <=> amino_acid + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
|
KEGG:
R08679
|
|
|
|
a_2-oxo_carboxylate + acetyl-CoA + H2O <=> 2-Alkylmalic_acid + CoA
|
2.3.3
|
–
|
|
|
KEGG:
R08680
|
|
|
|
Aliphatic_oxo_acid + amino_acid <=> Homoamino_acid + a_2-oxo_carboxylate
|
2.6.1
|
–
|
|
|
KEGG:
R08683
|
|
|
|
L-phenylalanine + a_2-oxo_carboxylate <=> phenylpyruvate + an_L-amino_acid
|
2.6.1
|
–
|
K
|
|
KEGG:
R10499
|
|
|
|
2-oxo-4-phenylbutanoic_acid + an_L-amino_acid <=> L-homophenylalanine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R10503
|
|
|
|
(S)-3-acetyloctanal + amino_acid <=> 2-Methyl-3-n-amyl-dihydropyrrole + a_2-oxo_carboxylate
|
2.6.1
|
–
|
K
|
|
KEGG:
R11672
|
|
|
|
a_2-oxo_carboxylate + L-asparagine <=> 2-oxosuccinamic_acid + proteinogenic_amino_acid
|
2.6.1.14
asparagine---oxo-acid transaminase
|
–
|
M
|
|
MetaCyc:
2.6.1.14-RXN
|
|
|
|
proteinogenic_amino_acid + H2O + O2 <=> a_2-oxo_carboxylate + NH3 + H2O2
|
1.4.3.2
L-amino-acid oxidase
|
–
|
|
|
MetaCyc:
L-AMINO-ACID-OXIDASE-RXN
|
|
|
|
L-ornithine + a_2-oxo_carboxylate <=> proteinogenic_amino_acid + L-glutamate_5-semialdehyde
|
2.6.1.13
ornithine aminotransferase
|
–
|
|
|
MetaCyc:
ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
|
|
|
|
L-methionine + a_2-oxo_carboxylate <=> 4-methylsulfanyl-2-oxobutanoate + proteinogenic_amino_acid
|
2.6.1.88
methionine transaminase
|
–
|
M
|
|
MetaCyc:
R15-RXN
|
|
|
|
electron-transfer_quinone + H2O + a_D-amino_acid <=> electron-transfer_quinol + a_2-oxo_carboxylate + NH3
|
1.4.5.1
D-amino acid dehydrogenase (quinone)
|
–
|
|
|
MetaCyc:
RXN-11193
|
|
|
|
(S)-ureidoglycine + a_2-oxo_carboxylate <=> Oxalureate + an_L-amino_acid
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-12221
|
|
|
|
(R)-2-hydroxyacid + electron-transfer_quinone <=> a_2-oxo_carboxylate + electron-transfer_quinol
|
1.1.5.10
D-2-hydroxyacid dehydrogenase (quinone)
|
–
|
|
|
MetaCyc:
RXN-14931
|
|
|
|
2-keto-5-phospho-3-cis-pentenoate + an_L-amino_acid <=> AppA + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXN-15547
|
|
|
|
2-keto-4-hydroxy-5-phosphopentanoate + an_L-amino_acid <=> 2-amino-4-hydroxy-5-phosphonopentanoate + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXN-15550
|
|
|
|
(S)-3-acetyloctanal + an_L-amino_acid <=> 2-Methyl-3-n-amyl-dihydropyrrole + a_2-oxo_carboxylate + H2O
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXN-15778
|
|
|
|
4-(4-hydroxyphenyl)-2-oxobutanoic_acid + amino_acid <=> L-hTyr + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXN-16496
|
|
|
|
4-hydroxy-4-methyl-2-oxoglutarate + an_L-amino_acid <=> 4-Hydroxy-4-methylglutamate + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXN-16958
|
|
|
|
5-methylthio-2-oxopentanoate + proteinogenic_amino_acid <=> L-homomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXN-2205
|
|
|
|
S-methyl-L-methionine + a_2-oxo_carboxylate + H+ <=> 3-dimethylsulfoniopropionaldehyde + CO2 + proteinogenic_amino_acid
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-9759
|
|
|
|
a_2-oxo_carboxylate + NH3 + e- + H+ <=> a_D-amino_acid + H2O
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-6678
|
|
|
|
6-methylthio-2-oxohexanoate + proteinogenic_amino_acid <=> L-dihomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXNQT-4345
|
|
|
|
7-methylthio-2-oxoheptanoate + proteinogenic_amino_acid <=> L-trihomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXNQT-4346
|
|
|
|
8-methylthio-2-oxooctanoate + proteinogenic_amino_acid <=> L-tetrahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXNQT-4347
|
|
|
|
9-methylthio-2-oxononanoate + proteinogenic_amino_acid <=> L-pentahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXNQT-4348
|
|
|
|
2-Oxo-10-methylthiodecanoate + proteinogenic_amino_acid <=> L-hexahomomethionine + a_2-oxo_carboxylate
|
2.6.1
|
–
|
M
|
|
MetaCyc:
RXNQT-4349
|
|
|
|
L-leucine + a_2-oxo_carboxylate <=> 4-methylsulfanyl-2-oxobutanoate + an_aliphatic_L-amino_acid
|
2.6.1.88
methionine transaminase
|
–
|
|
|
BRENDA:
BS417159
|
|
|
|
L-asparagine + a_2-oxo_carboxylate <=> 2-oxosuccinamic_acid + amino_acid
|
2.6.1.14
asparagine---oxo-acid transaminase
|
–
|
|
|
BRENDA:
BR47456
|
|
|
|
an_aliphatic_L-amino_acid + H2O + 2 cytochrome_b <=> a_2-oxo_carboxylate + NH3 + 2 reduced_cytochrome_b
|
1.4.99.B3
|
–
|
|
|
BRENDA:
BR52094
|
|
|
|
a_2-oxo_carboxylate + reduced_methyl_viologen <=> (R)-2-hydroxyacid + methyl_viologen
|
1.1.99.30
2-oxo-acid reductase
|
–
|
|
|
BRENDA:
BS371730
|
|
|
|
E1b-thiamine_diphosphate + a_2-oxo_carboxylate <=> E1b-thiamine_diphosphate-acyl + CO2
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
|
|
BRENDA:
BS373148
|
|
|
|
a_2-oxo_carboxylate + reduced_benzyl_viologen <=> (R)-2-hydroxyacid + Oxidized_benzyl_viologen
|
1.1.99.30
2-oxo-acid reductase
|
–
|
|
|
BRENDA:
BS371729
|
|
|
|
L-m-Tyr + pyridoxal_5'-phosphate <=> pyridoxamine_5'-phosphate + a_2-oxo_carboxylate
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18639
|
|
|
|
L-serine + pyridoxal_5'-phosphate <=> pyridoxamine_5'-phosphate + a_2-oxo_carboxylate
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18640
|
|
|
|
L-alanine + pyridoxal_5'-phosphate <=> pyridoxamine_5'-phosphate + a_2-oxo_carboxylate
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18642
|
|
|
|
L-phenylalanine + pyridoxal_5'-phosphate <=> pyridoxamine_5'-phosphate + a_2-oxo_carboxylate
|
4.1.99.2
tyrosine phenol-lyase
|
–
|
|
|
BRENDA:
BS18641
|
|
|
|
(S)-2-hydroxyacid + acceptor <=> a_2-oxo_carboxylate + reduced_acceptor
|
1.1.99.B9
|
–
|
|
|
BRENDA:
BR52092
|
|
|
|
L-glutamine + a_2-oxo_carboxylate <=> 2-oxoglutarate + amino_acid
|
2.6.1.15
glutamine---pyruvate transaminase
|
–
|
|
|
BRENDA:
BS356329
|
|